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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Lago Costa, Nádia | es |
dc.contributor.author | Ferreira Oton-Leite1, Angélica | es |
dc.contributor.author | Peixoto Cheim-Júnior, Adonai | - |
dc.contributor.author | Gonçalves Alencar, Rita de Cássia | - |
dc.contributor.author | Jabur Bitta, Glória Oton | - |
dc.contributor.author | Aparecida Silva, Tarcília | - |
dc.contributor.author | Carvalho Batista, Aline | - |
dc.date.accessioned | 2013-09-24T11:34:24Z | - |
dc.date.available | 2013-09-24T11:34:24Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/36004 | - |
dc.description.abstract | Mast cells (MCs) display a diversity of roles that may contribute to the stromal microenvironment alterations during tumor progression. The aim of this study was to investigate MC populations expressing tryptase and c-kit in lip squamous cell carcinoma (lip SCC) (n=37), actinic cheilitis (AC) (n=15) and normal lip mucosa (control) (n=6), as well as their relationship with microscopic parameters (collagen degeneration, elastin changes, angiogenesis and proliferative index). Tryptase, c-kit, CD31 and Ki-67 expressions were analyzed by means of immunohistochemistry and collagen and elastic fibers were visualized with Picrosirus and Verhoeff’s stain, respectively. The numbers of tryptase+ MC were significantly higher in lip SCC when compared with control (P=0.01), while a similar density of these cells was observed in AC and lip SCC (P=0.09). The density of c-kit+ MC was similar in all groups examined (P=0.65). MC migration (ckit+/Tryptase+ relationship) was 69% in lip SCC, 60% in AC and 100% in control. The number of CD31+ blood vessels was significantly higher in the lip SCC when compared with control and AC (P<0.01). The increase of MCs and angiogenesis in lip SCC may reflect an important modification in the tumor microenvironment during squamous photocarcinogenesis. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Mast cells | es |
dc.subject | Lip squamus cell carcinoma | es |
dc.subject.other | 61 - Medicina | es |
dc.title | Density and migration of mast cells in lip squamous cell carcinoma and actinic cheilitis | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.24, nº4 (2009) |
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Fichero | Descripción | Tamaño | Formato | |
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Density and migration of mast cells in lip squamous cell carcinoma and actinic cheilitis.pdf | 2,82 MB | Adobe PDF | Visualizar/Abrir |
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