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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Knowles, H.J. | es |
dc.contributor.author | Athanasou, N.A. | es |
dc.date.accessioned | 2013-09-24T11:33:51Z | - |
dc.date.available | 2013-09-24T11:33:51Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/36000 | - |
dc.description.abstract | Physiological and pathological bone resorption is mediated by osteoclasts, multinucleated cells which are formed by the fusion of monocyte / macrophage precursors. The canonical pathway of osteoclast formation requires the presence of the receptor activator for NFkB ligand (RANKL) and macrophage colony stimulating factor (M-CSF). Noncanonical pathways of osteoclast formation have been described in which cytokines / growth factors can substitute for RANKL or M-CSF to induce osteoclast formation. Substitutes for RANKL include LIGHT, TNFa and interleukins 6, 11 and 8. M-CSF substitutes include vascular endothelial growth factor (VEGF), placental growth factor (PlGF), FLt-3 ligand and hepatocyte growth factor (HGF). These growth factors can also influence canonical (RANKL / M-CSFinduced) osteoclast formation. Both canonical and noncanonical pathways of osteoclast formation play a role in the formation of osteolytic lesions where there is increased osteoclast formation and activity, such as in giant cell tumour of bone. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Osteoclast | es |
dc.subject | Osteolysis | es |
dc.subject.other | 616 - Patología. Medicina clínica. Oncología | es |
dc.title | Canonical and non-canonical pathways of osteoclast formation | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.24, nº3 (2009) |
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Canonical and noncanonical pathways of osteoclast formation.pdf | 371,94 kB | Adobe PDF | Visualizar/Abrir |
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