Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/35996

Title: An overview of the pale and clear cells of the nipple epidermis
Issue Date: 2009
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: 616 - Patología. Medicina clínica. Oncología
Keywords: Clear cells
Breast carcinoma
Abstract: The stratified squamous epithelium of the nipple-areola complex may contain pale or clear cells including: Paget’s disease cells (PDCs), Toker cells (TCs), and so-called clear cells (CCs). Paget’s disease is an uncommon presentation of breast carcinoma. PDCs are large, atypical, have abundant, pale-staining cytoplasm that may contain mucin secretion vacuoles and bulky heterochromatic nuclei. They are commonly concentrated along the basal layer and stain for EMA, CAM5.2, cytokeratin 7, and HER2/neu oncoprotein. TCs are bland cells with roundish and scant chromatin nuclei. They are found incidentally and are reactive for EMA, CAM5.2, and cytokeratin 7, but show negativity for HER2/neu oncoprotein. So-called CCs show varied morphology, are found incidentally, and have been variably interpreted by different authors. The majority of cells that have been called epidermal CCs fit the features of pagetoid dyskeratosis. These cells are reactive for high molecular weight cytokeratin. Other CCs showing signet-ring morphology present negativity for mucins and correspond to a fixation artefact.
Primary author: Garijo, M.F.
Val, D.
Val-Bernal, José Fernando
Published in: Histology and histopathology
URI: http://hdl.handle.net/10201/35996
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 10
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.24, nº3 (2009)

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