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Título: | Ets transcription factors in intestinal morphogenesis, homeostasis and disease |
Fecha de publicación: | 2008 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Intestine Cancer |
Resumen: | Ets transcription factors comprise a large family of sequence-specific regulators of gene expression with important and diverse roles in development and disease. Most Ets family members are expressed in the developing and/or mature intestine, frequently in a compartment-specific and temporally dynamic manner. However, with the exception of the highly expressed Elf3, involved in embryonic epithelial differentiation, little is known about Ets functions in intestinal development and homeostasis. Ets factors show altered expression in colon cancer, where they regulate pathways relevant to tumor progression. Ets factors also likely act as important modifiers of nonneoplastic intestinal disease by regulating pathways relevant to tissue injury and repair. Despite a large body of published work on Ets biology, much remains to be learned about the precise functions of this large and diverse gene family in intestinal morphogenesis, homeostasis, and both neoplastic and non-neoplastic pathology. |
Autor/es principal/es: | Jedlicka, Paul Gutierrez-Hartmann, Arthur |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/29859 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.23,nº11 (2008) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Ets transcription factors in intestinal morphogenesis, homeostasis and disease.pdf | 1,35 MB | Adobe PDF | Visualizar/Abrir |
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