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Title: Sarcomatoid acquired cystic disease-associated renal cell carcinoma
Issue Date: 2008
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: 616.6 - Patología del sistema genitourinario
Keywords: Renal cell carcinoma
Abstract: In this article, we report a rare case of hitherto undescribed acquired cystic disease (ACD)- associated renal cell carcinoma (RCC) with sarcomatoid change. A 78-year-old woman had been receiving hemodialysis for fourteen years at the time when a renal tumor was encountered on the follow-up examination of the kidney. Microscopically, oncocytic cuboidal cells proliferated with tubular, cribriform or papillary growth patterns, and atypical columnar cells with abundant cytoplasm proliferated with papillary configuration. Oxalate crystal deposition was observed in the stroma and the tumor focally resembled translocation type (TFE3) RCC. Sarcomatous neoplastic cells were also seen. The cytoplasm of oncocytic and sarcomatous neoplastic cells was diffusely positive for antimitochondrial antibody and the ultrastructural examination detected many mitochondria in the cytoplasm of oncocytic carcinoma cells and sarcomatous neoplastic cells. The loss of chromosomes 1p, 2q11-22, 9 and 14 was observed using comparative genomic hybridization analysis. We thus report here a case of hitherto undescribed ACD-associated RCC intermingled with oncocytic cells, translocation type RCC-like area and sarcomatoid change. This is the sixth case of sarcomatoid RCC arising in end-stage kidney disease.
Primary author: Kuroda, Naoto
Tamura, Masato
Taguchi, Takahiro
Tominaga, Akira
Hes, Ondrej
Michal, Michal
Ohara, Masahiko
Hirouchi, Takashi
Mizuno, Keiko
Hayashi, Yoshihiro
Shuin, Taro
Lee, Gang-Hong
Published in: Histology and histopathology
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 5
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.23,nº11 (2008)

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