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Título: | a-Methylacyl coenzyme A racemase is highly expressed in the intestinal-type adenocarcinoma and high-grade dysplasia lesions of the stomach |
Fecha de publicación: | 2008 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 616.3 - Patología del aparato digestivo. Odontología |
Palabras clave: | Gastric carcinomas Dysplasia |
Resumen: | To study a-Methylacyl coenzyme A racemase (AMACR) expression in gastric intestinal-type adenocarcinoma and its precursors, we performed an immunohistochemical assay (using an avidin-biotinperoxidase complex method) on 106 paraffin-embedded gastric mucosal biopsy samples and 25 gastrectomy samples (37 negative for dysplasia; 30 indefinite for dysplasia; 22 low-grade dysplasia; 25 high-grade dysplasia; and 34 invasive intestinal adenocarcinoma). The results showed that AMACR staining was uniformly negative in the groups negative for dysplasia and indefinite for dysplasia. Only 1 of 22 (4.5%) low-grade dysplasia showed weak staining for AMACR. In the groups of high-grade dysplasia and invasive intestinaltype adenocarcinoma, however, 19 of 25 (76%) and 18 of 34 (52.9%) were positive for AMACR respectively. Expression of AMACR was not correlated with location, H. Pylori infection or intestinal metaplasia. These results suggested that AMACR may play a role in the intermediate stage of gastric carcinogenesis. The high level expression of AMACR in high-grade dysplasia and carcinoma suggests that it may be a useful biomarker in distinguishing high-grade dysplasia and carcinoma from low-grade dysplasia. |
Autor/es principal/es: | Huang, Wenbin Zhao, Jianhua Li, Li Huang, Yue Yang, Xiaobin Wang, Jinsong Zhang, Tonghai |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/29855 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.23,nº11 (2008) |
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a-Methylacyl coenzyme A racemase is highly expressed in the intestinal-type adenocarcinoma and high-grade dysplasia lesions of the stomach.pdf | 3,09 MB | Adobe PDF | Visualizar/Abrir |
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