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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Royuela, Mar | es |
dc.contributor.author | Rodríguez-Berriguete, Gonzalo | es |
dc.contributor.author | Fraile, Benito | - |
dc.contributor.author | Paniagua, Ricardo | - |
dc.date.accessioned | 2013-01-22T10:03:59Z | - |
dc.date.available | 2013-01-22T10:03:59Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/29840 | - |
dc.description.abstract | TNFa exerts apoptosis throughout an intracellular transduction pathway that involves the kinase proteins TRAF-2 (integration point of apoptotic and survival signals), ASK1 (pro-apoptotic protein), MEK-4 (p38 activator and metastasis suppressor gene), JNK (stress mitogen activated protein kinase) and the transcription factor AP-1. TNFa also exerts proliferation by p38 activation, or when TRAF-2 simultaneously induces the transcription factor NF-kB by NIK. NIK and p38 may also be activated by IL-1. P38 activated several transcription factors such as Elk-1, ATF-2 and NF-kB. NIK also may activate NF-kB. The aim of the present article was to evaluate the different components of this TNFa/IL-1 transduction pathway in human prostate carcinoma (PC) in comparison with normal human prostate. In prostate cancer, pro-apoptotic TNFa/AP-1 pathway is probably inactivated by different factors such as p21 (at ASK-1 level) and bcl-2 (at JNK level), or diverted towards p38 or NIK activation. IL-1a enhances proliferation through IL-1RI that activates either NIK or p38 transduction pathway. P38 and NIK activate different transcription factors related with cell proliferation and survival such as ATF-2, Elk-1 or NF-kB. In order to search a possible target to cancer prostate treatment we proposed that inhibition of several proinflamatory cytokines such as IL-1 and TNFa might be a possible target for PC treatment, because decrease the activity of all transduction pathway members that activate transcription factors as NF-kB, Elk-1 or ATF-2. | es |
dc.format | application/pdf | es |
dc.format.extent | 12 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Prostate carcinoma | es |
dc.subject.other | 576 - Biología celular y subcelular. Citología | es |
dc.title | TNF-aIL-1-NF-kB transduction pathway in human cancer prostate | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.23,nº10 (2008) |
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TNF-aIL-1-NF-kB transduction pathway in human cancer prostate.pdf | 2,56 MB | Adobe PDF | Visualizar/Abrir |
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