Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/29827

Título: SMARCC1 expression is upregulated in prostate cancer and positively correlated with tumour recurrence and dedifferentiation
Fecha de publicación: 2008
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: 616.6 - Patología del sistema genitourinario
Palabras clave: Prostate cancer
Androgen receptor
Resumen: Background. The identification of new prognostic markers in prostate cancer (PC) is essential to improve patient treatment and management. Data suggest that SMARCC1 protein, a part of the intranuclear SWI/SNF complex which enhances the transactivation of the androgen receptor, is upregulated in PC and therefore a possible candidate marker for PC progression. Materials. Expression of SMARCC1 immunostaining was analysed on a tissue microarray containing specimens from 327 patients with prostate cancer and clinical follow-up information. Furthermore, 30 specimens from patients with benign prostate hyperplasia were included as controls as well as 30 specimens of benign prostate tissue from PC patients. Also, 18 specimens from lymph node metastases were analysed. Results. All benign specimens showed no or minimal staining for SMARCC1. In contrast, 20% of the specimens from patients with non-metastatic and nonrecurrent disease showed moderate to marked staining. In 31% of the patients with recurrent disease and in 31% of the patients with metastatic disease we found moderate to strong SMARCC1 immunostaining. In total, 23% of lymph node metastases expressed SMARCC1. SMARCC1 expression was also positively correlated to Gleason score (p<0.05), clinical T stage (p<0.01) and time to recurrence (p<0.001). In a logistic regression analysis, patients with a marked SMARCC1 immunostaining had a significantly elevated odds ratio (OR) of 16 for recurrent cancer and an OR of 4.5 for metastatic disease. Conclusions. Our present results demonstrate an increased expression of SMARCC1 protein in prostate cancer and reveal a positive correlation with tumour dedifferentiation, progression, metastasis and time to recurrence.
Autor/es principal/es: Heebøll, S.
Borre, M.
Ottosen, P.D.
Andersen, C.L.
Mansilla, F.
Dyrskjøt, L.
Orntoft, T.F.
Tørring, N.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/29827
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 8
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.23, nº9 (2008)

Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.