Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/29808

Registro completo de metadatos
Campo DCValorLengua/Idioma
dc.contributor.authorLee, Li-Yues
dc.contributor.authorWu, Chi-Minges
dc.contributor.authorWang, Chee-Chan-
dc.contributor.authorYu, Jau-Song-
dc.contributor.authorLiang, Ying-
dc.contributor.authorHuang, Kuo-Hao-
dc.contributor.authorLo, Chih-Hong-
dc.contributor.authorHwang, Tsann-Long-
dc.date.accessioned2013-01-22T10:01:12Z-
dc.date.available2013-01-22T10:01:12Z-
dc.date.issued2008-
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/29808-
dc.description.abstractMatrix metalloproteinases (MMPs) MMP-2 and MMP-9 can degrade type IV collagen of extracellular matrix and basal membranes. Claudin-4 is a member of a large family of transmembrane proteins, claudins, essential in the formation and maintenance of tight junctions. Claudin-4 has been shown to activate MMP-2, indicating that claudin-mediated increased cancer cell invasion might be mediated through the activation of MMP proteins. To explore the roles of MMP-2, MMP-9 and claudin-4 in gastric cancer, we selected 88 cases and then analyzed the expression of these proteins using immunohistochemistry. We found that all of MMP-2, MMP-9 and claudin-4 expressions were significantly higher in intestinal-type than in diffuse-type gastric cancer. On further analysis, testing the relationship between MMP-2 and MMP-9 expression with claudin-4 expression, claudin-4 expression was significantly associated with MMP-9 expression, but not with MMP-2 expression. The results showed that MMP- 2, MMP-9 and claudin-4 expression may be phenotypic features, distinguishing intestinal-type and diffuse-type gastric cancer. Possibly, claudin-4 played a role in determining MMP-9 activity which favored intestinaltype gastric cancer to distal metastasis.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectClaudines
dc.subjectGastric canceres
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleExpression of matrix metalloproteinases MMP-2 and MMP-9 in gastric cancer and their relation to claudin-4 expressiones
dc.typeinfo:eu-repo/semantics/articlees
Aparece en las colecciones:Vol.23, nº5 (2008)



Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.