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Título: | Evidence for a potential tumor suppressor role for the Na,K-ATPase B1-subunit |
Fecha de publicación: | 2008 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Tumorigenicity Cell adhesion |
Resumen: | The Na,K-ATPase, consisting of two essential subunits (a, ß), plays a critical role in the regulation of ion homeostasis in mammalian cells. Recent studies indicate that reduced expression of the ß1 isoform (NaK-ß1) is commonly observed in carcinoma and is associated with events involved in cancer progression. In this study, we present evidence that repletion of NaK-ß1 in Moloney sarcoma virustransformed Madin-Darby canine kidney cells (MSVMDCK), a highly tumorigenic cell line, inhibits anchorage independent growth and suppresses tumor formation in immunocompromised mice. Additionally, using an in vitro cell-cell aggregation assay, we showed that cell aggregates of NaK-ß1 subunit expressing MSVMDCK cells have reduced extracellular regulated kinase (ERK) 1/2 activity compared with parental MSV-MDCK cells. Finally, using immunohistochemistry and fully quantitative image analysis approaches, we showed that the levels of phosphorylated ERK 1/2 are inversely correlated to the NaK-ß1 levels in the tumors. These findings reveal for the first time that NaK-ß1 has a potential tumor-suppressor function in epithelial cells. |
Autor/es principal/es: | Inge, Landon J. Rajasekaran, Sigrid A. Yoshimoto, Koji Mischel, Paul S. McBride, William Landaw, Elliot Rajasekaran, Ayyappan K. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/29794 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.23, nº4 (2008) |
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Evidence for a potential tumor suppressor role for the Na,K-ATPase B1-subunit.pdf | 1,07 MB | Adobe PDF | Visualizar/Abrir |
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