Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/29720

Full metadata record
DC FieldValueLanguage
dc.contributor.authorLinke, N.es
dc.contributor.authorBódi, N.es
dc.contributor.authorResch, B.E.-
dc.contributor.authorFekete, Eva-
dc.contributor.authorBagyánszki, M.-
dc.date.accessioned2013-01-18T13:36:19Z-
dc.date.available2013-01-18T13:36:19Z-
dc.date.issued2008-
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/29720-
dc.description.abstractThree vesicular glutamate transporters (VGLUT1-3) have previously been identified in the central nervous system, where they define the glutamatergic phenotype, and their expression is tightly regulated during brain development. In the present study we applied immunocytochemistry to examine the distribution of the immunoreactivity of all three VGLUTs during prenatal development of the myenteric plexus in the human small intestine. We also investigated changes in their localization in the different segments of the small intestine and in the different compartments of the developing myenteric ganglia. Immunoreactivity against all three VGLUTs was found predominantly in the ganglionic neuropil, interganglionic varicose fibers and perisomatic puncta, but cytoplasmic labeling with different intensities also occurred. Each transporter displayed a characteristic spatiotemporal expression pattern, with the transient increase or decrease of immunoreactive cell bodies, varicosities or perisomatic puncta, depending on the fetal age, the gut segment or the ganglionic compartment. Throughout gestational weeks 14-23, VGLUT1 immunoreactivity always predominated over VGLUT2 immunoreactivity, though both peaked around week 20. VGLUT3 immunoreactivity was less abundant in the developing myenteric plexus than those of VGLUT1 and VGLUT2 immunoreactivity. It was mainly expressed in the ganglionic neuropil and in the perisomatic puncta throughout the examined gestational period. Neuronal perikarya immunoreactive for VGLUT3 were restricted to between weeks 18 and 20 of gestation and exclusively to the oral part of the small intestine.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectMyenteric plexuses
dc.subjectHumanes
dc.subject.other61 - Medicinaes
dc.titleDevelopmental pattern of three vesicular glutamate transporters in the myenteric plexus of the human fetal small intestinees
dc.typeinfo:eu-repo/semantics/articlees
Appears in Collections:Vol.23, nº8 (2008)



Items in Digitum are protected by copyright, with all rights reserved, unless otherwise indicated.