Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/29711

Título: RECK, a novel matrix metalloproteinase regulator
Fecha de publicación: 2008
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: 61 - Medicina
Palabras clave: Metalloproteinases
Resumen: Extracellular matrix (ECM) macromolecules are important for creating the cellular environments required during development and morphogenesis of tissues. Matrix metalloproteinases (MMPs) are a family of Zn-dependent endopeptidases that collectively are capable of cleaving virtually all ECM substrates, and play an important role in some physiological and pathological processes. MMP activity can be inhibited by some natural and artificial inhibitors. A newly found membrane-anchored regulator of MMPs, the reversioninducing- cysteine-rich protein with kazal motifs (RECK), is downregulated when the cells undergo a process of malignant transformation, and is currently the subject of considerable research activity because of its specific structure and function. In this review, we have chosen to concentrate our efforts on the structure, function, regulation, and future prospect of RECK in order to provide a new target for prevention and treatment of tumours.
Autor/es principal/es: Meng, N.
Li, Y.
Zhang, H.
Sun, X-F.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/29711
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 8
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.23, nº8 (2008)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
RECK, a novel matrix metalloproteinase regulator.pdf369,5 kBAdobe PDFVista previa

Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.