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http://hdl.handle.net/10201/29702
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Yang, Jilong | es |
dc.contributor.author | Zhang, Wei | es |
dc.date.accessioned | 2013-01-18T13:35:19Z | - |
dc.date.available | 2013-01-18T13:35:19Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/29702 | - |
dc.description.abstract | Loss of heterozygosity and chromosomal rearrangement of the WWOX gene, which is located at 16q23.3-24.1, have been detected in ovarian, breast, hepatocellular, and prostate carcinomas and in other neoplasias. This gene, which spans the common chromosomal fragile site 16D, contains 9 exons and encodes a 46 kDa WWOX protein that contains 414 amino acids. The evidence from cancer cell lines and primary tumor tissues suggests that WWOX is a tumor suppressor gene and that its inactivation contributes to cancer development. The results from studies of WWOX gene knockout cancer cells and a WWOX knockout mouse model partly confirm this hypothesis. The nature of the various proteins that the WWOX protein can interact with, such as c-Jun, TNF, p53, p73, AP- 2gamma, and E2F-1, suggests that WWOX plays a central role in tumor suppression through transcriptional repression and apoptosis, with its apoptotic function the more prominent of the two. However, there is not universal agreement that WWOX is a tumor suppressor gene. Further analysis is needed to reveal the true nature of WWOX. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Tumor suppressor gene | es |
dc.subject | Apoptosis | es |
dc.subject.other | 616 - Patología. Medicina clínica. Oncología | es |
dc.title | WWOX tumor suppressor gene | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.23, nº7 (2008) |
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Fichero | Descripción | Tamaño | Formato | |
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WWOX tumor suppressor gene.pdf | 88,95 kB | Adobe PDF | ![]() Visualizar/Abrir |
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