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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Sánchez-Cordón, Pedro José | es |
dc.contributor.author | Romero-Trevejo, José Lorenzo | es |
dc.contributor.author | Pedrera, Mirian | - |
dc.contributor.author | Sánchez-Vizcaino, José Manuel | - |
dc.contributor.author | Bautista, María José | - |
dc.contributor.author | Gómez-Villamandos, José Carlos | - |
dc.date.accessioned | 2013-01-18T13:32:19Z | - |
dc.date.available | 2013-01-18T13:32:19Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/29691 | - |
dc.description.abstract | To ascertain the role played by the various liver monocyte-macrophage populations in the course of a viral hemorrhagic fever, fifteen pigs were inoculated intramuscularly with the highly virulent isolate of African Swine Fever Virus (ASFV) España-70 and slaughtered at 1-7 days post-inoculation (dpi). Samples of liver were fixed in different solutions and routinely processed for morphological, immunohistochemical and ultrastructural studies. Viral antigen (vp73) was detected from 3 dpi onward, mainly in circulating monocytes of sinusoid and Kupffer’s cells (KC), as well as in portal macrophages and hepatocytes from 5 dpi. Anti-SWC3 immunolabelled cells were increased from 1 dpi, peaking between 3 and 5 dpi, thereafter declining until the end of the experiment. The significant increase in the number of sinusoidal circulating monocytes and KC expressing IL-1a, TNFa and IL-6 from 1 dpi, confirmed the secretory activation of these cells. The results show that in the course of an ASFV-induced hemorrhagic syndrome, hepatic macrophage populations undergo major quantitative and biosynthetic changes prior to virus detection, suggesting the existence of a mechanism by which the virus concentrates infectable cells, which subsequently spread the virus around the body. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | African swine fever | es |
dc.subject | Cytokines | es |
dc.subject.other | 636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticos | es |
dc.title | Role of hepatic macrophages during the viral haemorrhagic fever induced by African Swine Fever Virus | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.23, nº6 (2008) |
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Role of hepatic macrophages during the viral haemorrhagic fever induced by African Swine Fever Virus.pdf | 2,29 MB | Adobe PDF | Visualizar/Abrir |
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