Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/29658

Título: Molecular mechanisms of medullary thyroid carcinoma, current approaches in diagnosis and treatment
Fecha de publicación: 2008
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: 616 - Patología. Medicina clínica. Oncología
Palabras clave: Medullary thyroid carcinoma
Tyrosine
Resumen: Medullary thyroid carcinoma is the most common cause of death among patients with multiple endocrine neoplasia (MEN) 2. Dominant-activating mutations in the RET proto-oncogene have been shown to have a central role in the development of MEN 2 and sporadic medullary thyroid cancer (MTC): about half of sporadic MTCs are caused by somatic genetic changes of the RET oncogene. Inactivating mutations of the same gene lead to Hirschprung disease and other developmental defects. Thus, RET genetic changes lead to phenotypes that largely depend on their location in the gene and the function and timing of developmental expression of the RET protein. The reproducibility of the phenotype caused by each RET genotype led to MEN 2/MTC being among the first conditions in Medicine where a drastic measure is applied to prevent cancer, following genetic testing: thyroidectomy is currently routinely done in young children that are carriers of MTC-predisposing RET mutations. RET inhibitors have been also developed recently and are used in various types of thyroid and other cancers. This report reviews the RET involvement in the etiology of MEN 2 and MTC and updates the therapeutic approach in preclinical and clinical studies.
Autor/es principal/es: Boikos, S.A.
Stratakis, C.A.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/29658
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 8
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.23, nº1 (2008)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Molecular mechanisms of medullary thyroid carcinoma, current approaches in diagnosis and treatment.pdf655,38 kBAdobe PDFVista previa
Visualizar/Abrir


Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.