Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10201/28484
Twittear
Título: | Expression of certain proteins in the subfornical organ and cerebrospinal fluid of spontaneously hypertensive rats |
Fecha de publicación: | 2007 |
Editorial: | Murcia: F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 61 - Medicina |
Palabras clave: | Cerebrospinal fluid Proteins |
Resumen: | The objective of this study was to analyze the proteins in the cerebrospinal fluid of spontaneously hypertensive rats and to study their possible role in the relationship between hydrocephalus, arterial hypertension and variations in the subfornical organ. Brains and cerebrospinal fluid from control Wistar- Kyoto rats and spontaneously hypertensive rats sacrificed with chloral hydrate were used. Cerebrospinal fluid and extract of subfornical organ were processed by protein electrophoresis. Antisera against protein bands of 141, 117 and 48 kDa and Concanavalin A were used for immunohistochemical and western blot study of the subfornical organ, adjacent circumventricular structures and cerebrospinal fluid. Ventricular dilation in the spontaneously hypertensive rats and the presence of quite a lot of protein bands in the cerebrospinal fluid of the hypertensive rats, which were either not observed or scarcely present in the cerebrospinal fluid of the Wistar- Kyoto rats, were confirmed. The subfornical organ, third ventricle ependyma and choroideus plexus showed immunoreactive material for antibodies against 141kDa, 117 and 48 kDa proteins band (anti-B1, anti-B2 and anti- B3). The larger amount of the immunoreactive material was found in the subfornical organ of the spontaneously hypertensive rat. Our results and the alterations observed by other authors in the subfornical organ in hydrocephalic and hypertensive rats support the possibility that this circumventricular organ, some proteins of the cerebrospinal fluid and ventricular dilation could be connected with the physiopathology of this type of hypertension. |
Autor/es principal/es: | Gonzalez-Marrero, I. Carmona-Calero, E. Fernández-Rodríguez, P. Pérez-González, H. Ormazabal-Ramos, C. Castañeyra-Ruíz, L. Perez-Garcia, C.G. Martínez de la Peña y Valenzuela, Isabel Castañeyra-Ruiz, A. Castañeyra Perdomo, A. Ferres Torres, R. |
Forma parte de: | Histology and histopathology, vol.22, nº12 (2007) |
URI: | http://hdl.handle.net/10201/28484 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.22, nº12 (2007) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Expression of certain proteins in the subfornical organ and cerebrospinal fluid of spontaneously hypertensive rats.pdf | 4,63 MB | Adobe PDF | Visualizar/Abrir |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.