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Title: Cell contribution of vasa-vasorum to early arterial intimal thickening formation
Issue Date: 2007
Publisher: Murcia: F. Hernández
ISSN: 0213-3911
Related subjects: 576 - Biología celular y subcelular. Citología
Keywords: Arterial adventitia
Abstract: In occluded femoral artery segments, intimal thickening occurred and abundant neovascularization from the surrounding microcirculation developed. Under these conditions, the contribution of vasa-vasorum as a source of supplementary population of cells during the early intimal thickening formation was studied. Using a technique that specifically labels venules, predominantly postcapillary venules, a marker-Monastral Blue B-was used as a tracer to follow the pericyte, endothelial cell and monocyte/macrophage lineages. In the first two days of the experiment, the marker was restricted to the wall of the periarterial microcirculation, being incorporated by endothelial cells, pericytes and some monocytes/macrophages crossing the venule walls. Later, the marker continues to be observed in some of the following cells: endothelial cells and pericytes of the newly-formed vessels, fibroblast-like cells, transitional cells between pericytes and fibroblast-like cells, macrophages migrating into the interstitium, myointimal cells and neoendothelial cells of the arterial lumen. These findings provide evidence that, during arterial intimal thickening formation in occluded arterial segments, the periarterial microvascularization contributes, in addition to recruited macrophages, newlyformed endothelial cells and a supplementary population of fibroblast-like cells and myointimal cells.
Primary author: Díaz-Flores Jr., L.
Madrid, J.F.
Gutiérrez, Ricardo
Varela, H.
Valladares, Francisco
Díaz-Flores, Lucio
Published in: Histology and histopathology, vol.22, nº12 (2007)
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 8
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.22, nº12 (2007)

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