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Título: | Experimental change on dopaminergic neurons in striatum of Parkinson disease rats |
Fecha de publicación: | 2007 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 615 - Farmacología. Terapéutica. Toxicología. Radiología |
Palabras clave: | Apomorphine Striatum |
Resumen: | Background: Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by selective and progressive demise of dopaminecontaining neurons in the midbrain. In this study, we observe the expression of c-Jun in the striatum of rats with 6-hydroxydopamine (6-OHDA)-lesions after apomorphine (APO) intraperitoneal injection (ip) in substantia nigra compacta (SNc), and to study the mechanism of the rotations behavior. Design: The 6- OHDA was unilaterally injected into rat right SNC. The APO- induced abnormal rotations were investigated on the 1st, 4th, 7th, 14th, 21st days after lesion, respectively. Meanwhile dopaminergic degeneration and c-Jun expression were observed with microscope. Nissl’s body staining and immunohistochemical method (ABC) were employed to study the changes of tyrosine hydroxylase (TH) and c-Jun in DA neurons. Results: We found that the number of dopaminergic neurons decreased gradually in the lesioned site and those neurons’ electron-microscopic structure was severe damaged. There were over 75% of dopaminergic neurons lost, contralateral rotations over 7 turns per minute and c-Jun expressing in the ipsilateral striatum. Conclusion: Dopaminergic neurons deletion may be linked to upregulation of c-Jun. |
Autor/es principal/es: | Chen, X.Y. Li, Jiang Qi, W.Q. Shen, S.H. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/27648 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.22, nº10 (2007) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Experimental change on dopaminergic neurons in striatum of Parkinson disease rats.pdf | 1,59 MB | Adobe PDF | Visualizar/Abrir |
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