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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Faronato, M. | es |
dc.contributor.author | Muzzonigro, G. | es |
dc.contributor.author | Milanese, G. | - |
dc.contributor.author | Menna, C. | - |
dc.contributor.author | Bonfigli, A.R. | - |
dc.contributor.author | Catalano, A. | - |
dc.contributor.author | Procopio, A. | - |
dc.date.accessioned | 2012-05-21T12:11:07Z | - |
dc.date.available | 2012-05-21T12:11:07Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/27642 | - |
dc.description.abstract | The clinical behaviour of Clear Cell Renal Cell Carcinoma (CC-RCC) is often unpredictable. To fully understand the signaling pathways involved in CCRCC development, we examined whether the 5- Lipoxygenase (5-LO), which catalyzes the biosynthesis of proinflammatory leukotrienes, is involved in renal tumorigenesis. By analyzing 46 snap-frozen primary renal cell carcinomas and their corresponding normal renal cortex biopsies, 5-LO protein levels were found to be significantly increased in the majority of CC-RCCs (P<0.001). Quantitative 5-LO mRNA expression analysis revealed up to 3-fold increased expression in the tumor tissues. There was no association between 5-LO and gender, grade or vein invasion. In contrast, increased 5-LO protein and mRNA correlated with large tumor size (>4 cm) and age of patients (P<0.001). 5-LO was frequently overexpressed in von Hippel-Lindau protein (pVHL)–reduced tumors and in Vascular Endothelial Growth Factor (VEGF)-positive tumors, which represent two frequent alterations in CC-RCC. Cell culture experiments demonstrated that VEGF expression was strongly inducible by 5-LO metabolites in RCC cell lines. The loss of pVHL expression led to high basal 5- LO and VEGF expression, which were markedly reduced by transfection with 5-LO small interfering RNA (siRNA). These results suggest that 5-LO upregulation is an important step in renal cancer progression. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Renal cell carcinoma | es |
dc.subject | Tumor progression | es |
dc.subject.other | 616.6 - Patología del sistema genitourinario | es |
dc.title | Increased expression of 5-lipoxygenase is common in clear cell renal cell carcinoma | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.22, nº10 (2007) |
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Increased expression of 5lipoxygenase is common in clear cell renal cell carcinoma.pdf | 4,36 MB | Adobe PDF | Visualizar/Abrir |
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