Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/27630

Título: Prenatal corticosterone influences the trajectory of neuronal development, delaying or accelerating aspects of the Purkinje cell differentiation
Fecha de publicación: 2007
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: 576 - Biología celular y subcelular. Citología
Palabras clave: Purkinje neurons
Prenatal glucocorticoids
Resumen: The nervous system developmental programs proceed in orderly fashion following strict timetables. However, the mechanisms regulating developmental timing remain largely unknown. Increases or decreases in glucocorticoids in the fetal brain can be detrimental. We present evidence supporting that corticosterone forwards the migration of cerebellar granule neurons when applied acutely during pregnancy. This change in developmental tempo enhances dendritic growth of Purkinje neurons, increases the nuclear area, accelerates perinucleolar rosette appearance and decreases the development of Nissl bodies. Our observations thus support that forwarding the occurrence of developmental events does not always arrest neuronal growth, as some heterochronic developmental models imply. We suggest that prenatal glucocorticoids alter the trajectory of Purkinje neurons development soon after birth. These changes could represent a transient condition or could produce medium or long-term later consequences. More studies are needed to evaluate these intriguing possibilities
Autor/es principal/es: Rugerio-Vargas, C.
Ramírez-Escoto, M.
DelaRosa-Rugerio, C.
Rivas-Manzano, P.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/27630
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 7
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.22, nº 9 (2007)



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