Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/27602

Título: Mechanisms of skeletal muscle degradation and its therapy in cancer cachexia
Fecha de publicación: 2007
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: 612 - Fisiología
Palabras clave: Cancer cachexia
Skeletal muscle
Resumen: Severe or chronic disease can lead to cachexia which involves weight loss and muscle wasting. Cancer cachexia contributes significantly to disease morbidity and mortality. Multiple studies have shown that the metabolic changes that occur with cancer cachexia are unique compared to that of starvation. Specifically, cancer patients seem to lose a larger proportion of skeletal muscle mass. There are three pathways that contribute to muscle protein degradation: the lysosomal system, cytosolic proteases and the ubiquitin (Ub)-proteasome pathway. The Ub-proteasome pathway seems to account for the majority of skeletal muscle degradation in cancer cachexia and is stimulated by several cytokines including tumor necrosis factor-a, interleukin-1ß, interleukin-6, interferon-g and proteolysis-inducing factor. Cachexia is particularly severe in pancreatic cancer and contributes significantly to the quality of life and mortality of these patients. Several factors contribute to weight loss in these patients, including alimentary obstruction, pain, depression, side effects of therapy and a high catabolic state. Although no single agent has proven to halt cachexia in these patients there has been some progress in the areas of nutrition with supplementation and pharmacological agents such as megesterol acetate, steroids and experimental trials targeting cytokines that stimulate the Ub-proteasome pathway.
Autor/es principal/es: Melstrom, L.G.
Melstrom Jr., K.A.
Ding, X.Z.
Adrian, T.E.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/27602
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 10
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.22, nº 7 (2007)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Mechanisms of skeletal muscle degradation and its therapy in cancer cachexia.pdf187,7 kBAdobe PDFVista previa

Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.