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Título: | Chromatin in embryonic stem cell neuronal differentiation |
Fecha de publicación: | 2007 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | 616.8 - Neurología. Neuropatología. Sistema nervioso |
Palabras clave: | Chromatin Neurons |
Resumen: | Chromatin, the basic regulatory unit of the eukaryotic genetic material, is controlled by epigenetic mechanisms including histone modifications, histone variants, DNA methylation and chromatin remodeling. Cellular differentiation involves large changes in gene expression concomitant with alterations in genome organization and chromatin structure. Such changes are particularly evident in self-renewing pluripotent embryonic stem cells, which begin, in terms of cell fate, as a tabula rasa, and through the process of differentiation, acquire distinct identities. Here I describe the changes in chromatin that accompany neuronal differentiation, particularly of embryonic stem cells, and discuss how chromatin serves as the master regulator of cellular destiny. |
Autor/es principal/es: | Meshorer, E. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/27563 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.22, nº 3 (2007) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Chromatin in embryonic stem cell neuronal differentiation.pdf | 789,06 kB | Adobe PDF | Visualizar/Abrir |
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