Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/27526

Title: Protection from oxidative stress by enhanced glycolysis; a possible mechanism of cellular immortalization
Issue Date: 2007
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: 61 - Medicina
Keywords: Glycolysis
Oxidative stress
Abstract: Reactive oxygen species (ROS) play a crucial role not only in the physiological signal transduction but also in the pathogenesis of several human diseases such as atherosclerosis, neurodegenerative diseases, metabolic disorders, aging or cancer amongst others. Oxidative stress is also responsible for cellular and organism senescence, in accordance with what Harman initially proposed in the free radical theory of aging. Recent findings support the notion that protection from oxidative stress can increase life span significantly. We reported that enhanced glycolysis could modulate cellular life span with reduction of oxidative stress. Moreover, the tumor suppressor gene p53 controls post-transcriptionally the level of the glycolytic enzyme, phosphoglycerate mutase (PGM). As enhanced glycolysis is a distinctive and prominent feature of cancer cells (termed the Warburg effect), our findings disclosed a novel aspect of the Warburg effect: the connection between senescence and oxidative stress.
Primary author: Kondoh, H.
Lleonart, M.E.
Bernard, D.
Gil, J.
Published in: Histology and histopathology
URI: http://hdl.handle.net/10201/27526
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 6
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.22, nº 1 (2007)



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