Estudio de la romifidina en sedación y anestesia disociativa felina

Abstract

En la primera parte se evalúan los efectos sedantes, adversos y sobre el sistema cardiorrespiratorio de la romifidina en la especie felina. Se utilizaron cinco y se realizaron 4 grupos experimentales: romifidina 200, 400 y 600 µg/Kg IM y medetomidina 80 µg/Kg IM. En la segunda parte se evalúa la combinación romifidina/ketamina en la especie felina. Se utilizaron siete gatos. Se realizaron 5 grupos experimentales: Romifidina 100 y 200 µg/Kg con ketamina 7,5 y 10 mg/Kg y romifidina 200 µg/Kg con ketamina 5 mg/Kg. Se monitorizó el grado de relajación muscular, la respuesta al clampado y el sistema cardiorrespiratorio durante 60 minutos. Los resultados obtenidos sugieren que el efecto sedante de la romifidina puede ser útil en premedicación anestésica y en intervenciones no dolorosas. La romifidina potencia la actividad de la ketamina, y su combinación compensa parcialmente los efectos adversos de la misma. Firstly, the sedative, cardio respiratory and adverse effects produced for the administration of romifidine were evaluated in five cats. Four experimental groups were established: romifidine 200, 400 and 600 µg/Kg in comparison to medetomidine 80 µg/Kg. Secondly, the anaesthetic quality, cardiorespiratory and adverse effects produced by the mixture of romifidine and ketamine were studied in seven cats. Five experimental groups were established: Romifidine 100 µg/Kg and ketamine 7.5 mg/Kg and 10 mg/Kg, romifidine 200 µg/Kg and ketamine 5 mg/Kg, 7.5 mg/Kg, and 10 mg/Kg. The drugs were administred intramuscularly. The results of this experience suggest that romifidine could be a good alternative as a sedative for the development of non-painful procedures, as well as anaesthetic pre-medication. Romifidine enhances the anaesthetic effects of ketamine and the disadvantages of each compound are well remedied in the combination. This mixture in combination wit h opioids could be a chance to perform minor surgery procedures