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Título: Increased collagen deposition correlated with lung destruction in human emphysema
Fecha de publicación: 2006
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: 61 - Medicina
Palabras clave: Functional study
Lm
Resumen: Background. To study the relationship between collagen amount and degree of emphysema as assessed by mean linear intercept (Lm) and correlating these with lung function test workup in patients with and without COPD. Methods. Lung function tests were assessed in 16 smokers or ex-smokers and 1 non-smoker in order to separate them into two groups: COPD (FEV1/FVC lower than 70%) and non-COPD. A piece of lung tissue was used to analyse the collagen amount (HYP) by means of a colorimetric method. Morphometry was assessed to divide patients into two groups according to Lm: Lm<260 µm was considered non-emphysema and Lm>260 mm mild-emphysema. Results. The non-emphysema group had a mean Lm value of 246.08±3.12 µm and the mild-emphysema group of 276.29±4.26 µm. The amount of hydroxyproline was significantly higher in the mildemphysema group than in the non-emphysema group (7.82±0.67 vs. 5.50±0.54 µg/g tissue). There was a clear positive correlation between Lm and HYP (r=0.55) and a negative correlation between Lm and DlCO (R= -0.5092). No correlation was found between the functional test and HYP, nor were there significant differences between COPD and non-COPD patients for Lm and HYP. Conclusions. Emphysema is associated with collagen deposition in the lungs, and air space size correlates with the amount of lung collagen even when there is no emphysema.
Autor/es principal/es: Martín Mosquero, C.
Peces-Barba, G.
Rubio, M.L.
Ortega, M.
Rodríguez-Nieto, M.J.
Martínez Galán, L.
González-Mangado, N.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/22688
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 6
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.21, nº 8 (2006)

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