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Title: The distribution pattern of myofibroblasts in the stroma of human bladder carcinoma depends on their invasiveness
Issue Date: 2006
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.6 - Patología del sistema genitourinario
Keywords: Human bladder carcinoma
Abstract: The presence of myofibroblasts has been elucidated in the stroma of neoplasm of various organs. In the present article, we studied the distribution of myofibroblasts in the stroma of bladder carcinoma. Twenty-five surgical resected bladder tumors (urothelial carcinoma, n=21; combined urothelial carcinoma and adenocarcinoma, n=2; sarcomatoid squamous cell carcinoma, n=1; combined urothelial carcinoma and squamous cell carcinoma, n=1) were selected and we evaluated the distribution of myofibroblasts using immunohistochemical, electron and immunoelectron microscopic techniques. Immunohistochemically, the distribution pattern of myofibroblasts in invasive and non-invasive carcinomas were predominantly fascicular and reticular forms, respectively. Moreover, myofibroblasts around bladder carcinoma cells were confirmed by electron microscope. Understanding the distribution pattern of myofibroblasts in the stroma of bladder carcinoma may provide available information about the presence of carcinoma invasion.
Primary author: Shimasaki, N.
Kuroda, Naoto
Miyazaki, E.
Hayashi, Yoshihiro
Toi, M.
Hiroi, Makoto
Enzan, H.
Shuin, T.
Published in: Histology and histopathology
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 5
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.21, nº 4 (2006)

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