Please use this identifier to cite or link to this item:
|Title:||8-weeks training program attenuates mitochondrial oxidative stress in the liver of emotionally stressed rats|
|Publisher:||Murcia : F. Hernández|
|Related subjects:||CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.8 - Neurología. Neuropatología. Sistema nervioso|
|Abstract:||In recent years it has been shown that emotional stress induced by immobilization may change the balance between pro-oxidant and antioxidant factors inducing oxidative damage. On the other hand, contradictory views exist concerning the role of physical activity on redox metabolism. Consequently, the present work was designed to assess the influence of an 8-week moderate swimming training program in emotionally stressed rats. Sixty 1-month-old male albino Wistar rats weighing 125-135 g were used in this experimental study. They were divided into three groups, as Control (lot A; n=20), Stressed (lot B; n=20) and Stressed & Exercised (lot C; n=20). Rats were stressed by placing the animals in a 25 x 7 cm plastic bottle 1 h/day, 5 days a week for 8 weeks. Protein carbonyl content values in liver homogenates were significantly increased in stressed animals (0.58±0.02 vs 0.86±0.03; p=0.018) which clearly indicated that emotional stress was associated with oxidative stress. Ultrastructural alterations, predominantly mitochondrial swelling and the decrease of cristae number observed by electron microscopy represented direct evidence of membrane injury. The most striking feature of our study was that we also found differences between stressed rats and stressed rats that performed our 8 week training program. Consequently our results highlight the potential benefit of a moderate training program to reduce oxidative damage induced by emotional stress since it attenuated protein oxidation and mitochondrial alterations.|
|Primary author:||Rosety-Rodriguez, M.|
Ordóñez Muñoz, F.J.
|Published in:||Histology and histopathology|
|Number of pages / Extensions:||4|
|Appears in Collections:||Vol.21, nº11 (2006)|
Files in This Item:
|8weeks training program attenuates mitochondrial oxidative stress in the liver of emotionally stressed rats.pdf||166,31 kB||Adobe PDF|
Items in Digitum are protected by copyright, with all rights reserved, unless otherwise indicated.