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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Yumura, W. | es |
dc.contributor.author | Imasawa, T. | es |
dc.contributor.author | Suganuma, S. | - |
dc.contributor.author | Ishigami, A. | - |
dc.contributor.author | Handa, S. | - |
dc.contributor.author | Kubo, S. | - |
dc.contributor.author | Joh, K. | - |
dc.contributor.author | Maruyama, N. | - |
dc.date.accessioned | 2011-06-30T12:01:40Z | - |
dc.date.available | 2011-06-30T12:01:40Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/22581 | - |
dc.description.abstract | An experimental model with accelerated but not drastic renal senescence seemed useful to recognize the mechanisms of how kidney function deteriorates with age. Senescence marker protein-30 (SMP30), whose expression decreased with age and was sexindependent, is mainly expressed in hepatocytes and proximal tubular cells. Therefore, we established a SMP30 deficient strain of mice with a C57BL/6 background by gene targeting to investigate whether this molecule is involved in renal tubular cell senescence. Male SMP30 knockout (SMP30Y/-) mice and male wild-type (SMPY/+) mice (n=5) aged 12 months were examined histologically. Their tubular epithelia showed the deposition of lipofuscin and the presence of senescence-associated ß-galactosidase (SA-ß-GAL). However, no tubular cells were atrophic. In electron microscopy, SMP30-KO mice showed markedly enlarged lysosomes containing an electron dense substance. These are convincing hallmarks of senescence. We recognized the early manifestation of senescence hallmarks in SMP30-KO mice at 12 months old. Thus, this model represents the first report of a mouse strain that manifests accelerated ordinal senescence in a kidney after gene manipulation. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Renal senescence | es |
dc.subject | Tubular cells | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Accelerated tubular cell senescence in SMP30 knockout mice | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.21, nº11 (2006) |
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Fichero | Descripción | Tamaño | Formato | |
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Accelerated tubular cell senescence in SMP30 knockout mice.pdf | 4,13 MB | Adobe PDF | Visualizar/Abrir |
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