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Título: | Antiangiogenic and radiotherapy for cancer treatment |
Fecha de publicación: | 2006 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Angiogenesis Ionizing radiation |
Resumen: | Tumor growth and progression depends on tumor angiogenesis, the growth of tumor blood vessels, therefore, targeting tumor angiogenesis is a very promising approach for controlling tumor growth and/or causing regression. Tumor blood vessels have been recognized as a critical component of radiation response to the point of being independent of tumor oxygenation during radiation. An anti-angiogenic approach has been considered less likely to develop drug resistance. But recent findings suggest that anti-angiogenesis causes hypoxia that selects tumor cells (due to genetic instability) that are less dependent on blood supply and leads to drug resistance. The approach of combination of anti-angiogenesis with ionizing radiation by targeting both endothelial and tumor cells should minimize this possibility. The combination may produce a synergistic anti-tumor effect. |
Autor/es principal/es: | Kobayashi, H. Lin, P.C. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/22572 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.21, nº10 (2006) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Antiangiogenic and radiotherapy for cancer treatment.pdf | 133,03 kB | Adobe PDF | Visualizar/Abrir |
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