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Título: To NO or not to NO, where, is the question
Fecha de publicación: 2004
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Nitric oxide
Intracellular localization
Resumen: Nitric oxide (NO) is a gaseous radical with unique biological functions essential for the cardiovascular system, host defense and neurotransmission. For two decades it was thought that NO was able to diffuse freely across relatively long distances and to traverse major parts of the cell, if not multiple cell layers. However, NO has been proven to be extremely reactive: it reacts with other reactive oxygen species, heavy metals, as well as with cysteine and tyrosine residues in proteins. In accordance, it is now widely accepted that once NO is generated, it is very short-lived and diffuses only over a short distance. This urges for the local production of NO and the localization of NO synthases in the proximity of their downstream targets. This review discusses the highly organized localization of NO synthases, with the endothelial isoform (eNOS) as its main focus, since from this synthase most is known about its subcellular localization and regulation.
Autor/es principal/es: Govers, R.
Oess, S.
Publicado en: Histology and histopathology
URI: http://hdl.handle.net/10201/21568
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 21
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.19, nº 2 (2004)

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