Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/21520

Full metadata record
DC FieldValueLanguage
dc.contributor.authorKuroda, Naotoes
dc.contributor.authorToi, M.es
dc.contributor.authorNakayama, Hiroyuki-
dc.contributor.authorMiyazaki, E.-
dc.contributor.authorYamamoto, M.-
dc.contributor.authorHayashi, Yoshihiro-
dc.contributor.authorHiroi, Makoto-
dc.contributor.authorEnzan, H.-
dc.date.accessioned2011-06-08T09:04:32Z-
dc.date.available2011-06-08T09:04:32Z-
dc.date.issued2004-
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/21520-
dc.description.abstractTo elucidate the distribution and role of myofibroblasts and CD34-positive stromal cells in various pancreatic lesions, we performed an immunohistochemical study using a streptoavidin-biotin immunoperoxidase technique. We selected 43 pancreatic lesions from 1 biopsied, 22 surgically resected and 12 autopsied specimens: acute pancreatitis (n=3), chronic non-obstructive pancreatitis (n=4), obstructive pancreatitis (n=7), islet cell tumor (n=4), serous cystadenoma (n=7), mucinous cystadenoma (n=6), and invasive ductal carcinoma (n=12). In normal pancreas, myofibroblasts and CD34-positive stromal cells were predominantly present in the peridcutal and periacinar areas, respectively. Both myofibroblasts and CD34- positive cells were observed in the stroma of chronic pancreatitis. In four islet cell tumors, myofibroblasts were present in the stroma of the tumor center, but no CD34-positive stromal cells were identified. Additionally, myofibroblasts and CD34-positive stromal cells were located in the inner layer and the outer layer of the capsule of three islet cell tumors, respectively. In nine of the thirteen cystadenomas, only myofibroblasts were recognized in the cyst wall. In the remaining four cystadenomas, a small number of CD34-positive cells were observed in the cyst wall. In 12 invasive ductal carcinomas, the stroma possessed a lot of myofibroblasts, but there were no or few CD34-positive stromal cells. In conclusion, it seems that the abundant amount of CD34-stromal cells in the main lesions is characteristic of chronic inflammatory lesions. Myofibroblasts and CD34-positive stromal cells may play a role in regulating the tumor growth in the capsule of islet cell tumors of the pancreas.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectPancreases
dc.subjectMyofibroblastses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.4 - Patología del sistema linfático, órganos hematopoyéticos, endocrinoses
dc.titleThe distribution and role of myofibroblasts and CD34-positive stromal cells in normal pancreas and various pancreatic lesionses
dc.typeinfo:eu-repo/semantics/articlees
Appears in Collections:Vol.19, nº 1 (2004)

Files in This Item:
File Description SizeFormat 
The distribution and role of.pdf6,24 MBAdobe PDFThumbnail
View/Open


Items in Digitum are protected by copyright, with all rights reserved, unless otherwise indicated.