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Título: | Distribution of DMT 1 within the human glandular system |
Fecha de publicación: | 2003 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Glandulae Pancreas |
Resumen: | Background & Aims: DMT1 is a transmembrane protein which transports the divalent metal ions Fe2+, Zn2+, Cu2+ and Mn2+. Although DMT1 has been functionally linked to duodenal absorption and cellular utilisation of iron hardly anything is known about its distribution and potential role within the human glandular system. Methods: Two polyclonal antibodies were raised to study the expression of DMT1 in tissues obtained from human corpus by the means of immunocytochemistry and Western blotting. Results: All antibodies specifically detected a 60 kD protein band referring to human DMT1. Significant amounts of DMT1 expression were detected on the luminal site of organs, which are involved in excretion/re-absorption processes, such as salivary glands, pancreas, biliary tract and gallbladder. Conclusions: Our results suggest that DMT1 may be of pivotal importance for the regulation of metal ion homeostasis within organs involved in absorption and excretion of ions. |
Autor/es principal/es: | Koch, R.O. Zoller, H. Theurl, I. Obrist, P. Egg, G. Strohmayer, W. Vogel, W. Weiss, G. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/21479 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 7 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.18, nº 4 (2003) |
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Fichero | Descripción | Tamaño | Formato | |
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Distribution of DMT 1 within the human glandular system.pdf | 1,21 MB | Adobe PDF | Visualizar/Abrir |
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