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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Trovato, M. | es |
dc.contributor.author | Grosso, Maddalena | es |
dc.contributor.author | Vitarelli, E. | - |
dc.contributor.author | Ruggeri, R.M. | - |
dc.contributor.author | Alesci, S. | - |
dc.contributor.author | Trimarchi, F. | - |
dc.contributor.author | Barresi, G. | - |
dc.contributor.author | Benvenga, S. | - |
dc.date.accessioned | 2011-06-08T09:02:40Z | - |
dc.date.available | 2011-06-08T09:02:40Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/21416 | - |
dc.description.abstract | Hepatocyte growth factor (HGF), HGF receptor (c-met) and the interleukin 6 (IL-6) are expressed in thyroid nodules. In extra-thyroidal tissues, the HGF/c-met and IL-6/IL-6 receptor (IL-6R) systems activate STAT3, a member of the signal transducers and activators of transcription (STATs) family. To evaluate whether either system utilizes STAT3 in thyroid nodules, we examined the immunohistochemical expression of HGF, c-met, IL-6, IL-6R, STAT3 in 6 normal thyroids and in 68 thyroid nodules. STAT3 expression was observed in 12/12 (100%) papillary thyroid carcinomas (PTC) but in none of the follicular tumors. Among benign thyroid nodules, only 2/10 (20%) follicular adenomas (FA) were STAT3+. All these 14 STAT3+ cases expressed both HGF and c-met, but only 5 PTC co-expressed IL-6 and IL-6R and the 2 FA were IL-6+ but IL-6R-. The remaining 8 FA were all HGF-/c-met-, but IL-6+; of these 8, only 2 were also IL- 6R+. In conclusion, in thyroid nodules STAT3 is expressed only in PTC and a number of FA. Since these cases are consistently HGF+/c-met+ and only one-third of them co-express IL-6/IL-6R, STAT3 expression correlates with the HGF/c-met expression, not with the IL-6/IL-6R expression. The 100% rate of expression of the HGF/c-met/STAT3 signaling in PTC could be relevant for the establishment of the papillary phenotype. Because of the communeness of a HGF/c-met/STAT3 pattern between all PTC and a subset of FA, we speculate that a fraction of FA may progress to PTC. | es |
dc.format | application/pdf | es |
dc.format.extent | 7 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Hepatocyte growth factor | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Distinctive expression of STAT3 in papillary thyroid carcinomas and a subset of follicular adenomas | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.18, nº 2 (2003) |
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Distinctive expression of STAT3 in papillary thyroid.pdf | 1,32 MB | Adobe PDF | Visualizar/Abrir |
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