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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Kusakabe, T. | es |
dc.contributor.author | Hirakawa, H. | es |
dc.contributor.author | Matsuda, H. | - |
dc.contributor.author | Kawakami, T. | - |
dc.contributor.author | Takenaka, T. | - |
dc.contributor.author | Hayashida, Y. | - |
dc.date.accessioned | 2011-06-08T09:02:37Z | - |
dc.date.available | 2011-06-08T09:02:37Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/21412 | - |
dc.description.abstract | The distribution and abundance of neuropeptide-containing nerve fibers were examined in the carotid bodies of rats exposed to hypocapnic hypoxia (10% O2 in N2) for 2, 4, and 8 weeks. The carotid bodies after 2, 4, and 8 weeks of hypoxic exposure were enlarged by 1.2-1.5 times in the short axis, and 1.3-1.7 times in the long axis in comparison with the normoxic control ones. The enlarged carotid bodies contained a number of expanded blood vessels. Mean density per unit area (104 µm2) of substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactive fibers was transiently high in the carotid bodies after 4 weeks of hypoxic exposure, and decreased significantly to nearly or under 50% after 8 weeks of hypoxic exposure. Density of vasoactive intestinal polypeptide (VIP) immunoreactive fibers increased significantly in all periods of hypoxic exposure observed, and was especially high in the carotid bodies after 4 weeks of hypoxic exposure. Density of neuropeptide Y immunoreactive fibers was unchanged in the carotid bodies during hypoxic exposure. These characteristic changes in the density of SP, CGRP, and VIP fibers in the carotid bodies after 4 weeks of hypoxic exposure suggest that the role of these neuropeptide-containing fibers may be different in the carotid bodies after each of three periods of hypoxic exposure, and that the peptidergic innervation after 8 weeks of hypoxic exposure may show an acclimatizing state. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Rat | es |
dc.subject | Immunohistochemistry | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Peptidergic innervation in the rat carotid body after 2, 4, and 8 weeks of hypocapnic hypoxic exposure | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.18, nº 2 (2003) |
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Peptidergic innervation in the rat carotid body.pdf | 4,33 MB | Adobe PDF | Visualizar/Abrir |
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