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Título: | Knocked out by Rho Rac T-cell biology |
Fecha de publicación: | 2002 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | T cell maturation T cell signaling |
Resumen: | The Rho/Rac family is a group of Ras-related proteins with demonstrated roles in the regulation of proliferation and cytoskeletal structures in a number of cell lineages. Despite this, the actual role of these proteins in T-cells could not be addressed in vivo due to the lack of adequate animal models. Recently, the use of knockout and transgenic animals for Rac1, Rac2, and RhoA has provided a genetic proof of the importance of Rho/Rac protein in different aspects of T-cell signaling. These animals have also allowed us to get better views about the influence of these GTPases proteins on the maturation decisions of immature lymphocytes and on the signaling strategies these GTPases utilize to favor the generation of coherent and robust immune responses. |
Autor/es principal/es: | Bustelo, X.R. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/20830 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 5 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.17, nº 3 (2002) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Knocked out by Rho Rac Tcell biology.pdf | 79,36 kB | Adobe PDF | Visualizar/Abrir |
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