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Título: | Intergenic mRNAs. Minor gene products or tools of diversity? |
Fecha de publicación: | 2002 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::615 - Farmacología. Terapéutica. Toxicología. Radiología |
Palabras clave: | Trans-splicing PremRNA |
Resumen: | The general model of gene e x p r e s s i o n implies that the units of genetic information, the genes, constitute the basis of the mRNA and protein products detected in living organisms. It is well known that in eukaryotic cells a single gene may give rise to va r i o u s gene products due to alternative splicing and/or different positions of transcriptional start and termination. H ow eve r, recent experimental results suggest that in addition to this variation in gene expression, another l evel of complexity may also exist as evidence for the presence of mRNAs that combine sequence information ( exons) from distinct genes is accumulating. Moreove r, the mechanisms that allow this production of intergenic mRNAs are starting to unravel and it appears that these f o l l ow two general pathways: (a) bypass of transcriptional termination, resulting in the generation of bicistronic pre-mRNAs; and (b) authentic trans-splicing events between pre-mRNAs of distinct genes. |
Autor/es principal/es: | Finta, C. Warner, S.C. Zaphiropoulos, P.G. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/20788 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.17, nº 2 (2002) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Intergenic mRNAs. Minor.pdf | 176,24 kB | Adobe PDF | Visualizar/Abrir |
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