Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/20707

Título: Ultrastructural observations on the microvasculature in advanced gastric carcinomas
Fecha de publicación: 2001
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina
Palabras clave: Electron microscopy
Perivascular fibrosis
Resumen: The ultrastructural features associated with vascular permeability in 9 cases of advanced gastric carcinomas were studied, and compared with that of control non-neoplastic mucosa. Tumour rnicrovasculature showed features in common with those of control mucosa, including complete basa1 lamina, welldeveloped interendothelial junctions, fenestrations and caveolae. Some tumour blood vessels showed endothelial cell swelling accompained by luminal narrowing and perivascular fibrosis. In 2 out of 9 cases, there were endothelial attenuation with numerous fenestrations and vesiculo-vacuolar organelles. The vesiculo-vacuolar organelle is a recently described cytoplasmic structure found in the endothelial cells lining turnour microvessels and normal venules and which provides an important pathway for extravasation of circulating macromolecules. Our ultrastructural data suggest that advanced gastric carcinomas share with experimental tumour models in vivo only some morphologic features associated with hyperpermeability including fenestration, endothelial attenuation and vesiculo-vacuolar organelles. The implications of perivascular fibrosis on the delivery of immune cells to gastric carcinomas are discussed.
Autor/es principal/es: Caruso, R.A.
Speciale, G.
Inferrera, A.
Rigolis, L.
Inferrera, C.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/20707
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 8
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.16, nº 3 (2001)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Ultrastructural observations on the microvasculature in advanced gastric carcinomas.pdf4,46 MBAdobe PDFVista previa
Visualizar/Abrir


Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.