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Título: | Human skin reconstruct models: A new application for studies of melanocyte and melanoma biology |
Fecha de publicación: | 2001 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.5 - Piel. Dermatología clínica |
Palabras clave: | Melanoma Melanocyte |
Resumen: | Studies of melanocyte and melanoma biology using monocultures of cells are limited because of culture-induced morphology changes and expression of genes related to growth, migration, and invasion, which do not reflect the in situ phenotype of normal melanocytes, nevus cells, or melanoma cells from biologically early progression stages. The development of organotypic cultures of human skin, in which culture artifacts are greatly diminished and cell-matrix and cellcell interactions between different cell types can be investigated in a three-dimensional system, has opened a new era for melanoma research. Long-term in vivo studies, especially important for melanomagenesis and melanoma metastasis have become possible through grafting of skin reconstructs to immuno.deficient laboratory animals. In this review, principles and different methods of skin reconstruction are introduced with focus on the application for pigment cell biology |
Autor/es principal/es: | Berking, C. Herlyn, M. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/20677 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.16, nº 2 (2001) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Human skin reconstruct models A new application.pdf | 3,48 MB | Adobe PDF | Visualizar/Abrir |
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