Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/10201/20677

Título: Human skin reconstruct models: A new application for studies of melanocyte and melanoma biology
Fecha de publicación: 2001
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.5 - Piel. Dermatología clínica
Palabras clave: Melanoma
Melanocyte
Resumen: Studies of melanocyte and melanoma biology using monocultures of cells are limited because of culture-induced morphology changes and expression of genes related to growth, migration, and invasion, which do not reflect the in situ phenotype of normal melanocytes, nevus cells, or melanoma cells from biologically early progression stages. The development of organotypic cultures of human skin, in which culture artifacts are greatly diminished and cell-matrix and cellcell interactions between different cell types can be investigated in a three-dimensional system, has opened a new era for melanoma research. Long-term in vivo studies, especially important for melanomagenesis and melanoma metastasis have become possible through grafting of skin reconstructs to immuno.deficient laboratory animals. In this review, principles and different methods of skin reconstruction are introduced with focus on the application for pigment cell biology
Autor/es principal/es: Berking, C.
Herlyn, M.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/20677
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 6
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.16, nº 2 (2001)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Human skin reconstruct models A new application.pdf3,48 MBAdobe PDFVista previa
Visualizar/Abrir


Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.