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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Yamada, E. | es |
dc.contributor.author | Tobe, T. | es |
dc.contributor.author | Yamada, H. | - |
dc.contributor.author | Okamoto, N. | - |
dc.contributor.author | Zack, D.J. | - |
dc.contributor.author | Werb, Z. | - |
dc.contributor.author | Soloway, P.D. | - |
dc.contributor.author | Campochiaro, P.A. | - |
dc.date.accessioned | 2011-05-11T10:55:31Z | - |
dc.date.available | 2011-05-11T10:55:31Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/20634 | - |
dc.description.abstract | Proteolysis of vascular basement membranes and surrounding extracellular matrix is a critica1 early step in neovascularization. It requires alteration of the balance between matrix metalloproteinases (MMPs) and proteins that bind to and inactivate MMPs, tissue inhibitors of metalloproteinases (TIMPs). TIMP-1 has been demonstrated to inhibit neovascularization in chick chorioallantoic membranes. However, TIMP-1 has also been shown to either promote or inhibit cell proliferation and migration in different settings. To determine whether genetic alteration of the MMPDIMP-1 ratio would alter retinal neovascularization, we crossed mice that express vascular endothelial growth factor (VEGF) in photoreceptors with TIMP-1-deficient mice or mice that overexpress TIMP-1. Compared to VEGF transgenepositive/ TIMP-1-sufficient mice, VEGF transgenepositive1TIMP- 1-deficient mice showed smaller neovascular lesions. There was also no difference between the two groups of mice in the appearance of the neovascularization by light or electron microscopy. Compound VEGFITIMP-1 transgenic mice had increased expression of both VEGF and TIMP-1 in the retina, and had more neovascularization than mice that had increased expression of VEGF alone. These gainand loss-of-function data suggest that alteration of the TIMP-1MMP ratio modulates retinal neovascularization in a complex manner and not simply by altering the proteolytic activity and thereby invasiveness of endothelial cells. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | VEGF | es |
dc.subject | Retinal neovascularization | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::617 - Cirugía. Ortopedia. Oftalmología | es |
dc.title | TIMP-1 promotes VEGF-induced neovascularization in the retina | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.16, nº 1 (2001) |
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Fichero | Descripción | Tamaño | Formato | |
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TIMP1 promotes VEGFinduced neovascularization in the retina.pdf | 5,76 MB | Adobe PDF | Visualizar/Abrir |
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