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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Chen, Y.L. | es |
dc.contributor.author | Wu, H.W. | es |
dc.contributor.author | Jlang, M.J. | - |
dc.date.accessioned | 2011-02-22T11:21:23Z | - |
dc.date.available | 2011-02-22T11:21:23Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/19312 | - |
dc.description.abstract | Transforming growth factor-l31 (TGF-l31) has been shown to modulate both cell proliferation and the synthesis of extracellular matrix by vascular cells. This study was aimed to establish the temporal correlation between TGF-l31 expression, the expression of the extracellular matrix protein fibronectin, and plaque development during atherogenesis of hypercholesterolemic rabbits. New Zealand White rabbits were fed with 2% cholesterol-supplemented chow for 1 week, 2 weeks, 3 weeks or 6 weeks. TGF-l31 mRNA and protein expression was examined in serial sections of aorta by in situ hybridization and immunohistochemistry. Fibronectin expression was examined by immunohistochemistry. In the control and l-week feeding group, the expression of TGF-l31 mRNA and protein was not apparent. In 2-week feeding group, intimal thickening was detected in which TGF-B1 mRNA and protein were not clearly observed, either. The 3-week and 6-week feeding groups exhibited fatty streaks in which TGF-l31 mRNA and protein expression markedly increased as feeding proceeded. Cell typespecific staining indicated that TGF-l31 was expressed by macrophages as well as smooth muscle cells of the fatty streaks. Immunostaining of fibronectin detected low expression levels in control, l-week and 2-week feeding groups with pronounced upregulation in the thickened intima and the proximal media in 3-week and 6-week feeding groups. These results implicate a role for TGF-l31 in modulating fatty streak formation and the synthesis of extracellular protein fibronectin during plaque development. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Fibronectins | es |
dc.subject | Immunohistochemistry | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Transforming growth factor-01 gene and protein expression associated with atherogenesis of cholesterol-fed rabbits | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.15, nº 2 (2000) |
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Transforming growth factor01 gene and protein expression associated with atherogenesis of cholesterolfed rabbits.pdf | 4,51 MB | Adobe PDF | Visualizar/Abrir |
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