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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Rebuffat, P. | es |
dc.contributor.author | Neri, G. | es |
dc.contributor.author | Bahgelioglu, M. | - |
dc.contributor.author | Malendowicz, L.K. | - |
dc.contributor.author | Nussdorfer, G.G. | - |
dc.date.accessioned | 2011-02-22T11:21:19Z | - |
dc.date.available | 2011-02-22T11:21:19Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/19307 | - |
dc.description.abstract | The effects on the pituitary-adrenocortical functions of the prolonged (7-day) blockade of endogenous bradykinin (BK) synthesis, obtained by the administration of the kallikrein inhibitor (K-I) cyclohexylacetyl-Phe-Arg-Ser-Val-Gln amide, were investigated in the rat. K-I treatment did not cause significant changes in the (i) body and adrenal weights; (ii) basal plasma levels of ACTH, aldosterone and corticosterone; and (iii) average volume of adrenocortical cells and their basal secretory capacity. Conversely, K-I administration induced a significant magnification of the in vivo mineralo- and glucocorticoid responses to the intraperitoneal (i.p.) bolus injection of ACTH. Moreover, K-I-treated rats, but not control ones, displayed a moderate and short-term adrenal secretory response to the mild stress evoked by the placebo i.p. injection. Collectively, these findings rule out the possibility that endogenous BK plays a relevant role in the control of adrenocortical function under basal conditions. However, they suggest that endogenous BK may be involved in quenching exceedingly high adrenocortical responses to ACTH and stresses. | es |
dc.format | application/pdf | es |
dc.format.extent | 4 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Bradykinin | es |
dc.subject | Adrenal cortex | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Prolonged kallikrein inhibition does not affect the basal growth and secretory capacity of rat adrenal cortex, but enhances mineralo- and glucocorticoid response to ACTH and handling stress | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.15, nº 2 (2000) |
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Prolonged kallikrein inhibition does not affect the basal growth and secretory capacity of rat adrenal cortex but enhances mineralo and.pdf | 1,82 MB | Adobe PDF | Visualizar/Abrir |
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