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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Turunen, N. | es |
dc.contributor.author | Paakko, P. | es |
dc.contributor.author | Solni, Y. | - |
dc.date.accessioned | 2011-02-22T11:20:14Z | - |
dc.date.available | 2011-02-22T11:20:14Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/19283 | - |
dc.description.abstract | In this study we investigated apoptosis and the expression of caspases 3, 6 and 8 and bcl-2, mcl-l and bax in 39 gallbladder carcinomas and 7 epithelia1 dysplasias. The average apoptotic index was 0.68+0.91%. The extent of apoptosis was higher in grade 11-111 than grade I tumours or epithelial dysplasias (p=0.003). Also, tumours invading beyond serosa or into other organs (T3-T4) had a higher apoptotic index than other tumours (p=0.05). Caspase 3 expression was found in 37 (95%) and caspase 6 and 8 expression each in 30 (77%) carcinomas. Their expression associated with each other and tended to increase along with the progression of the lesions. Bcl-2 expression was found in only 4 (10%) tumours. In contrast, mcl-l positivity was found in 34 (87%) and bax positivity in all cases. The results show that apoptosis is increased along with progression of the neoplastic lesion of the gallbladder epithelium. Caspases 3,6 and 8 are strongly expressed in gallbladder carcinomas suggesting that they contribute to the increased apoptosis observed in them. Of the bcl-2 family proteins, bcl-2 was expressed infrequently suggesting that it does not play any significant role in apoptosis inhibition in gallbladder tumours. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Gallbladder | es |
dc.subject | Carcinoma | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Apoptosis in gallbladder carcinomas and dysplasias, its relation to the expression of caspases 3,6 and 8 and apoptosis regulating proteins bcl-2, mcl-l and bax | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.15, nº 1 (2000) |
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Fichero | Descripción | Tamaño | Formato | |
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Apoptosis in gallbladder carcinomas and dysplasias its relation to the expression of caspases 36 and 8 and.pdf | 5,2 MB | Adobe PDF | Visualizar/Abrir |
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