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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Xing, Z. | es |
dc.date.accessioned | 2011-02-22T11:20:11Z | - |
dc.date.available | 2011-02-22T11:20:11Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/19280 | - |
dc.description.abstract | Macrophages are important effector cells in cell-mediated immunity against intracelllular infection. Among cytokines that macrophages are able to release are IL-12 and TNFa. IL-12 is a critical linker between the innate and adaptive cell-mediated immunity, capable of Thl differentiation and IFNy release by T and NK cells. IFNy is critically required for the activation of macrophage bactericidal activities. Recently emerging evidence suggests that macrophages are able to release not only IL-12 and TNFa but also IFNy. However, the mechanisms that control the release of each of these type 1 cytokines in macrophages appear different. While macrophages release TNFa in an indiscriminate and IL- 12-independent way, the release of IL-12, particularly bioactive IL-12 p70, and IFNy is under tight control. We are just beginning to understand what controls the release of IL-12 p70, a question of fundamental importance to understanding the mechanisms underlying the initiation of cell-mediated immunity. Our recent findings have shed more insights into the regulatory mechanisms of macrophage IFNy responses. It has become evident that IL-12 is required not only for Thl differentiation but also for IFNy responses by both T cells and macrophages during intracellular infection. In this overview, we have discussed about the current understanding of the regulation of macrophage type 1 cytokine responses during intracellular infection, based upon the recent findings from us and others. | es |
dc.format | application/pdf | es |
dc.format.extent | 7 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Mycobacteria | es |
dc.subject | Intracellular infection | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Current understanding of macrophage type 1 cytokine responses during intracellular infections | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.15, nº 1 (2000) |
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Current understanding of macrophage type 1 cytokine responses during intracellular infections.pdf | 4,84 MB | Adobe PDF | Visualizar/Abrir |
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