Please use this identifier to cite or link to this item: http://hdl.handle.net/10201/19276

Title: Apoptosis in cancer: therapeutic implications
Issue Date: 2000
Publisher: Murcia : F. Hernández
ISSN: 0213-3911
Related subjects: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Keywords: Cancer
Apoptosis
Abstract: This review outlines the principal limitations of the mechanisms of active cell death (ACD, apoptosis) as the basis of tumorigenesis and the rationale of almost all therapies of malignancy. The concentration of cancer therapy in the directon of ACD induction is presented as both the result of progressive understanding of the mechanisms of apoptosis and that of the favourable tumor environment for ACD signal transmission. The latter property induces the by-stander killing of cancer cells, a fundamental mechanism because efficiency of all known methods of cancer treatment is far below 100%. Finally, recent results and hypotheses regarding cancer gene therapy based on final inductors of apoptosis and endogeneous ACD inhibitors in tumors are evaluated.
Primary author: Negoescu, A.
Published in: Histology and histopathology
URI: http://hdl.handle.net/10201/19276
Document type: info:eu-repo/semantics/article
Number of pages / Extensions: 17
Rights: info:eu-repo/semantics/openAccess
Appears in Collections:Vol.15, nº 1 (2000)

Files in This Item:
File Description SizeFormat 
Apoptosis in cancer therapeutic implications.pdf12,45 MBAdobe PDFView/Open


Items in Digitum are protected by copyright, with all rights reserved, unless otherwise indicated.