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Título: | Effect of hypertension on the angiotensin II fibres arriving at the posterior lobe of the hypophysis of the rat. An immunohistochemical study |
Fecha de publicación: | 2000 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::611 - Anatomía |
Palabras clave: | Hypophysis Angiotensin |
Resumen: | We studied immunohistochemically the posterior lobe of the hypophysis (PL) of 15-week-old spontaneously hypertensive rats (SHR) and of matched normotensive Wistar Kyoto rats (WKY), by using our own polyclonal antibody raised in mice against Angiotensin I1 (mouse-antiangiotensin 11, MAAII). The blood pressure, water intake and volume of the PL were also recorded. The SHR rats were hypertensive, drank more water and showed a clear hypertrophy of their hypophysial PL. Also the PL of the SHR animals showed an increase in the immunoreactivity to the antiangiotensin I1 antibody in the fibres arriving at the PL, with respect to the PL of WKY rats. This increase is compatible with the hyperactivity of the brain RAS, depletion of vasopressin content in the PL and increase in plasmatic levels of vasopressin described in SHR rats with respect to normotensive animals, as angiotensin I1 could locally stimulate vasopressin release to plasma from the neurohypophysis. |
Autor/es principal/es: | Pérez Delgado, M.M. Carmona-Calero, E. Marrero-Gordillo, N. Pérez-González, H. Castañeyra Perdomo, A. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/19273 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 5 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.15, nº 1 (2000) |
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Effect of hypertension on the angiotensin II fibres arriving at the posterior lobe of the hypophysis of the rat. An immunohistochemical study.pdf | 2,2 MB | Adobe PDF | Visualizar/Abrir |
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