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Título: Human papillomaviruses and DNA ploidy in anal condylomata acuminata
Fecha de publicación: 2000
Editorial: Murcia : F. Hernández
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.5 - Piel. Dermatología clínica
Palabras clave: Human papillomavirus
DNA ploidy
Resumen: Previous studies have emphasized the usefulness of DNA ploidy measurement and Human Papillomavirus (HPV) detection as pronostic markers in low grade cervical lesions. We addressed the eventual relationship between HPV type, DNA profile, and p53 tumor suppressor protein expression in anal condylomata acuminata to eventually determine parameters which may be considered as predictive risk factors for the development of cancer. DNA ploidy was assessed by image cytometry after Feulgen staining of contiguous serial sections of 45 anal condylomata acuminata without atypia containing HPV detected by in situ hybridization and Polymerase Chain Reaction (PCR). p53 expression was detected by immunohistochemistry. DNA aneuploidy was found in 53.3% of these lesions, 48.9% containing non oncogenic HPV types 6 andtor 11 and 4.4% harbouring HPV types 11 and 18. The DNA diploid lesions were all associated with non oncogenic HPV types 6 andtor 11 and one case also contained HPV type 33. There was no significant correlation between the detection of DNA aneuploidy and the presence of immunodetected p53. DNA aneuploidy was not related to the presence of oncogenic HPV in anal condylomata acuminata. The DNA aneuploid profile frequently observed, especially in lesions associated with non oncogenic HPV types, is not yet well explained and cannot be considered as a prognostic factor. In contrast, a more intensive clinical follow-up should be proposed in patients with oncogenic HPV associated to DNA aneuploidy.
Autor/es principal/es: Rihet, S.
Bellaich, P.
Lorenzato, M.
Bouttens, D.
Bernard, P.
Birembaut, P.
Clavel, C.
Forma parte de: Histology and histopathology
URI: http://hdl.handle.net/10201/19260
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 6
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Vol.15, nº 1 (2000)

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