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dc.contributor.authorHuang, W.H.es_ES
dc.contributor.authorZheng, M.H.es_ES
dc.date.accessioned2011-02-22T11:10:20Z-
dc.date.available2011-02-22T11:10:20Z-
dc.date.issued1999-
dc.identifier.issn0213-3911es_ES
dc.identifier.urihttp://hdl.handle.net/10201/19254-
dc.description.abstractSteroid hormones have an important impact on bone. The mechanism of steroid action on bone cells is through an interaction with specific receptor proteins in the target cells. Steroid receptors are a class of molecules that function as both signal transducers and transcription factors. The receptors each have similar functional domains that are responsible for discrete functions. The mechanism of receptor action is mediated by both genomic and nongenomic pathways. It is believed that in genomic pathway the steroid passes through the cell membrane by passive diffusion and binds to the receptor within the nucleus. Steroids have direct action on osteoblasts via receptor, and the effects of steroids on osteoclastic bone resorption are mediated through osteoblasts which release soluble factors by the action of hormone-receptor binding. However, in addition to indirect effects on osteoclasts, the question whether steroid hormones could exert direct action on osteoclasts as well has not to be answered and findings to date are controversial. It is not doubt that understanding the precise molecular mechanism of steroid action on bone resorption will develop new approaches for the diagnosis and treatment of disease associated with osteoclastic bone resorption.es_ES
dc.formatapplication/pdfes_ES
dc.format.extent12es_ES
dc.languageenges_ES
dc.publisherMurcia : F. Hernándezes_ES
dc.relation.ispartofHistology and histopathologyes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectEstrogenes_ES
dc.subjectProgestinses_ES
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes_ES
dc.titleSteroid hormones and bonees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
Aparece en las colecciones:Vol.14, nº 4 (1999)

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