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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Hochol, A. | es |
dc.contributor.author | Markowska, A. | es |
dc.contributor.author | Meneghelli, V. | - |
dc.contributor.author | Jedrzejczak, N. | - |
dc.contributor.author | Majchrzak, M. | - |
dc.contributor.author | Nowak, M. | - |
dc.contributor.author | Nussdorfer, G.G. | - |
dc.contributor.author | Malendowicz, L.K. | - |
dc.date.accessioned | 2011-02-22T11:09:58Z | - |
dc.date.available | 2011-02-22T11:09:58Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/19240 | - |
dc.description.abstract | Neurotensin (NT) and bombesin (BM)-like peptides are known to be involved in the regulation of the rat hypothalamo-pituitary-adrenal axis. By using selective NT- and BM-receptor antagonists (NT-A and BM-A, respectively) we investigated whether endogenous NT and BM-like peptides play a role in the control of rat adrenal secretion and growth during enucleation-induced regeneration. At day 5 of regeneration, NT-A did not affect the plasma concentrations of aldosterone (PAC) and corticosterone (PBC), but at day 8, it raised both PAC and PBC over the respective baseline value; the simultaneous administration of NT abolished this effect of NT-A. BMA did not alter PAC and PBC at day 5 of regeneration, while at day 8 it enhanced PBC, an effect reversed by BM. NT-A did not alter mitotic index, and BM-A lowered it at both day 5 and day 8 of regeneration, an effect suppressed by the simultaneous administration of BM. Collectively, these findings allow us to draw the following conclusions: 1) endogenous NT and BM-like peptides influence adrenocortical regeneration in rats; 2) NT exerts a tonic inhibitory action on both aldosterone and corticosterone secretion, without affecting cellproliferation rate; and 3) BM-like peptides exert a tonic suppressive effect on corticosterone production, coupled with a clear-cut stimulating effect on cell proliferation. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Neurotensin | es |
dc.subject | Rat | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina | es |
dc.title | Effects of neurotensin and bombesin on the secretory and proliferative activity of regenerating rat adrenal cortex | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.14, nº 4 (1999) |
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