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Título: | The possible role of colligin, HSP47, a collagen-binding protein, in the pathogenesis of human and experimental fibrotic diseases |
Fecha de publicación: | 1999 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Collagen Glomerulosclerosis |
Resumen: | Colligin or heat shock protein 47 (HSP47) is a stress protein that resides in the endoplasmic reticulum and is thought to participate in intracellular processing, folding, assembly and secretion of procollagens. Irrespective of the tissue site and organ, induction of colliginlHSP47 expression is always noted during the process of fibrosis, particularly in and around the fibrotic lesions in both humans and experimental models. Its expression is highly tissue- and cell-specific, and restricted to mostly phenotypically altered collagenproducing cells. These observations suggest that upregulation of this collagen-specific chaperone-colliginl HSP47 may play an important role in the subsequent fibrotic process, possibly by regulating increased synthesis/assembly of collagens. |
Autor/es principal/es: | Razzaque, M.S. Taguchi, T. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/19235 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 14 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.14, nº 4 (1999) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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The possible role of colligin HSP47 a collagenbinding protein in the pathogenesis of human and experimental fibrotic diseases.pdf | 9,29 MB | Adobe PDF | Visualizar/Abrir |
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