Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10201/19190
![](/digitum/image/email_logo.png)
![](/digitum/image/logo-facebook.png)
Título: | lmmunohistochemical analysis for cell proliferation-related protein expression in small cell carcinoma of the esophagus a comparative |
Fecha de publicación: | 1999 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina |
Palabras clave: | Esophagus Apoptosis |
Resumen: | Small cell carcinoma is a rare neoplasm in the esophagus. To evaluate cell proliferation activity and its underlying mechanisms in this tumor, we examined immunohistochemically 5 cases of small cell carcinoma of the esophagus (SCCE) for expressions of tumor suppressor proteins, oncoproteins and cell proliferation markers including p53, p21WAF1/C1P1r,e tinoblastoma (Rb) protein, bcl-2, Ki-67 and PCNA, and compared the results with those of 5 cases of small cell carcinoma of the lung (SCCL) and 10 cases of squamous cell carcinoma of the esophagus (SQCE). The prevalence and labeling index of p53-immunoreactivity tended to be higher in SCCE (415; 56.6%) and SCCL (415; 79.9%) than in SQCE (6110; 48.8%). Expression of p21wAFl/C1P1w as observed in 2 of 10 cases of SQCE. In contrast, its expression could not be detected in any cases of SCCE and SCCL examined. Expression of Rb protein was observed in 9 out of 10 cases of SQCE, but not in any cases of SCCE and SCCL. SCCE and SCCL showed more frequent and intense immunoreactivity for bcl-2 than SQCE. In expression of cell proliferation markers (Ki-67 and PCNA), no remarkable difference was observed among SCCE, SCCL and SQCE. These results suggest that SCCE and SCCL could share some genetic alternations including mutation of p53, loss of Rb gene and overexpression of bcl-2, and these may be related to the similar biological potentials between the two. Futhermore, SCCE was different from SQCE in expression of Rb protein and bcl-2, and these two types of esophageal carcinoma could arise through different molecular mechanisms. |
Autor/es principal/es: | Okudela, K. Ito, T. Kameda, Y. Nakamura, N. Kitamura, H. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/19190 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 7 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.14, nº 2 (1999) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
lmmunohistochemical analysis for cell proliferationrelated protein expression in small cell carcinoma of the esophagus a comparative.pdf | 4,73 MB | Adobe PDF | ![]() Visualizar/Abrir |
Los ítems de Digitum están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.